GLP-1
GLP-1 receptor
Brain satiety, delayed gastric emptying.
Binds to receptors in the hypothalamus and amplifies central satiety signals. Gastric transit slows down — portions shrink, satiety lasts longer.
Mechanism of Action
Three receptors. One molecule. A new metabolism.
Retatrutide is the first synthetic peptide that simultaneously modulates three key metabolic receptors. Each contributes distinctly — the combination is more than the sum of its parts.
GIP
GIP receptor
Insulin sensitivity and lipid metabolism.
Improves peripheral insulin sensitivity and modulates lipolysis. Fat stores are mobilized more efficiently, postprandial glucose spikes are reduced.
Glucagon
Glucagon receptor
Directly raises basal metabolic rate.
The decisive novelty: glucagon-receptor activation raises basal energy burn. The body burns more calories at rest — independent of exercise or diet.
Why the combination matters
Mono-agonists like Semaglutide address only the satiety signal. Dual-agonists like Tirzepatide add insulin metabolism. Retatrutide also targets basal energy expenditure — interrupting the metabolic compensation with which the body usually sabotages any diet.
Treatment available
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